Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Casp3  caspase 3   (Synonyms: A830040C14Rik, AC-3, Apopain, Caspase-3, CC3, CPP32, mldy, Yama)
Results	Reference
1	J:240005 Aldiri I, Ajioka I, Xu B, Zhang J, Chen X, Benavente C, Finkelstein D, Johnson D, Akiyama J, Pennacchio LA, Dyer MA, Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma. Development. 2015 Dec 01;142(23):4092-106
1	J:171630 Bagheri-Fam S, Argentaro A, Svingen T, Combes AN, Sinclair AH, Koopman P, Harley VR, Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome. Hum Mol Genet. 2011 Jun 1;20(11):2213-24
1	J:152698 Baguma-Nibasheka M, Kablar B, Abnormal retinal development in the Btrc null mouse. Dev Dyn. 2009 Aug 24;238(10):2680-2687
1	J:123909 Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N, Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82
1	J:241566 Chi L, Ahmed A, Roy AR, Vuong S, Cahill LS, Caporiccio L, Sled JG, Caniggia I, Wilson MD, Delgado-Olguin P, G9a controls placental vascular maturation by activating the Notch Pathway. Development. 2017 Jun 01;144(11):1976-1987
1	J:101353 Colombo E, Bonetti P, Lazzerini Denchi E, Martinelli P, Zamponi R, Marine JC, Helin K, Falini B, Pelicci PG, Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol. 2005 Oct;25(20):8874-86
1	J:242861 Damiani D, Goffinet AM, Alberts A, Tissir F, Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors. Nat Commun. 2016 Nov 16;7:13509
1	J:146618 Dasgupta B, Milbrandt J, AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development. Dev Cell. 2009 Feb;16(2):256-70
1	J:155846 de Lange FJ, Moorman AF, Anderson RH, Manner J, Soufan AT, de Gier-de Vries C, Schneider MD, Webb S, van den Hoff MJ, Christoffels VM, Lineage and morphogenetic analysis of the cardiac valves. Circ Res. 2004 Sep 17;95(6):645-54
1	J:237345 Dee A, Li K, Heng X, Guo Q, Li JY, Regulation of self-renewing neural progenitors by FGF/ERK signaling controls formation of the inferior colliculus. Development. 2016 Oct 15;143(20):3661-3673
1	J:77297 Di Cunto F, Imarisio S, Hirsch E, Broccoli V, Bulfone A, Migheli A, Atzori C, Turco E, Triolo R, Dotto GP, Silengo L, Altruda F, Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Neuron. 2000 Oct;28(1):115-27
1	J:266784 Gay MH, Valenta T, Herr P, Paratore-Hari L, Basler K, Sommer L, Distinct adhesion-independent functions of beta-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biol. 2015 Apr 11;13:24
1	J:243226 Geraud C, Koch PS, Zierow J, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin HG, Schledzewski K, Goerdt S, GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 2017 Mar 01;127(3):1099-1114
1	J:217045 Heng YH, McLeay RC, Harvey TJ, Smith AG, Barry G, Cato K, Plachez C, Little E, Mason S, Dixon C, Gronostajski RM, Bailey TL, Richards LJ, Piper M, NFIX regulates neural progenitor cell differentiation during hippocampal morphogenesis. Cereb Cortex. 2014 Jan;24(1):261-79
1	J:90847 Hirota J, Mombaerts P, The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8751-5
1	J:163030 Horn Z, Ringstedt T, Blaesse P, Kaila K, Herlenius E, Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism. Eur J Neurosci. 2010 Jun;31(12):2142-55
1	J:84726 Joswig A, Gabriel HD, Kibschull M, Winterhager E, Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways. Reprod Biol Endocrinol. 2003 May 26;1(1):44
1	J:291131 Kasamatsu A, Uzawa K, Hayashi F, Kita A, Okubo Y, Saito T, Kimura Y, Miyamoto I, Oka N, Shiiba M, Ito C, Toshimori K, Miki T, Yamauchi M, Tanzawa H, Deficiency of lysyl hydroxylase 2 in mice causes systemic endoplasmic reticulum stress leading to early embryonic lethality. Biochem Biophys Res Commun. 2019 May 7;512(3):486-491
1	J:114468 Konishi Y, Ikeda K, Iwakura Y, Kawakami K, Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis. Brain Res. 2006 Oct 20;1116(1):93-102
1	J:169855 Kroger C, Vijayaraj P, Reuter U, Windoffer R, Simmons D, Heukamp L, Leube R, Magin TM, Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues. Am J Pathol. 2011 Apr;178(4):1578-90
1	J:342552 Kulikauskas MR, Oatley M, Yu T, Liu Z, Matsumura L, Kidder E, Ruter D, Bautch VL, Endothelial cell SMAD6 balances Alk1 function to regulate adherens junctions and hepatic vascular development. Development. 2023 Nov 1;150(21)
1	J:156014 Lagha M, Brunelli S, Messina G, Cumano A, Kume T, Relaix F, Buckingham ME, Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors. Dev Cell. 2009 Dec;17(6):892-9
1*	J:71150 Leonard JR, D'Sa C, Cahn BR, Korsmeyer SJ, Roth KA, Bid regulation of neuronal apoptosis. Brain Res Dev Brain Res. 2001 Jun 29;128(2):187-90
1	J:213998 Li J, Duarte T, Kocabas A, Works M, McConnell SK, Hynes MA, Evidence for topographic guidance of dopaminergic axons by differential Netrin-1 expression in the striatum. Mol Cell Neurosci. 2014 Jul;61:85-96
1	J:264403 Li Q, Jiao J, Li H, Wan H, Zheng C, Cai J, Bao S, Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling. J Cell Sci. 2018 Jul 25;131(14):jcs217406
1	J:126240 Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Breant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A, The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004 Nov 11;432(7014):179-86
1	J:288654 Lun MP, Shannon ML, Keles S, Reisli I, Luche N, Ryan D, Capuder K, Notarangelo LD, Lehtinen MK, Spatiotemporal Gradient of Cortical Neuron Death Contributes to Microcephaly in Knock-In Mouse Model of Ligase 4 Syndrome. Am J Pathol. 2019 Dec;189(12):2440-2449
1	J:165487 Magnani D, Hasenpusch-Theil K, Jacobs EC, Campagnoni AT, Price DJ, Theil T, The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence. J Neurosci. 2010 Oct 13;30(41):13883-94
1	J:171425 Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM 3rd, Hofmann I, Mostov KE, Reichardt LF, p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011 May;138(10):2099-109
1	J:194050 Massa F, Garbay S, Bouvier R, Sugitani Y, Noda T, Gubler MC, Heidet L, Pontoglio M, Fischer E, Hepatocyte nuclear factor 1beta controls nephron tubular development. Development. 2013 Feb;140(4):886-96
1	J:199453 Mithal DS, Ren D, Miller RJ, CXCR4 signaling regulates radial glial morphology and cell fate during embryonic spinal cord development. Glia. 2013 Aug;61(8):1288-305
1	J:303747 Moffat JJ, Jung EM, Ka M, Jeon BT, Lee H, Kim WY, Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex. Sci Rep. 2021 Feb 16;11(1):3856
1	J:229930 Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G, The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife. 2016;5:e09584
1	J:154276 Ohsawa S, Hamada S, Yoshida H, Miura M, Caspase-mediated changes in histone H1 in early apoptosis: prolonged caspase activation in developing olfactory sensory neurons. Cell Death Differ. 2008 Sep;15(9):1429-39
1	J:187968 Okano J, Kimura W, Papaioannou VE, Miura N, Yamada G, Shiota K, Sakai Y, The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves. Dev Dyn. 2012 Nov;241(11):1744-56
1	J:311910 Papachristou P, Dyberg C, Lindqvist M, Horn Z, Ringstedt T, Transgenic increase of Wnt7b in neural progenitor cells decreases expression of T-domain transcription factors and impairs neuronal differentiation. Brain Res. 2014 Aug 12;1576:27-34
1	J:142505 Parlato R, Kreiner G, Erdmann G, Rieker C, Stotz S, Savenkova E, Berger S, Grummt I, Schutz G, Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice. J Neurosci. 2008 Nov 26;28(48):12759-64
1	J:191071 Petzold KM, Naumann H, Spagnoli FM, Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas. Development. 2013 Jan 1;140(1):126-35
1	J:203031 Rainger J, Keighren M, Keene DR, Charbonneau NL, Rainger JK, Fisher M, Mella S, Huang JT, Rose L, van't Hof R, Sakai LY, Jackson IJ, FitzPatrick DR, A Trans-Acting protein effect causes severe eye malformation in the Mp mouse. PLoS Genet. 2013;9(12):e1003998
1	J:96251 Ren J, Shi M, Liu R, Yang QH, Johnson T, Skarnes WC, Du C, The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):565-70
1*	J:264207 Rodgers HM, Huffman VJ, Voronina VA, Lewandoski M, Mathers PH, The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification. Mech Dev. 2018 Jun;151:18-29
1	J:109774 Roy K, Kuznicki K, Wu Q, Sun Z, Bock D, Schutz G, Vranich N, Monaghan AP, The Tlx gene regulates the timing of neurogenesis in the cortex. J Neurosci. 2004 Sep 22;24(38):8333-45
1	J:202654 Sauls K, de Vlaming A, Harris BS, Williams K, Wessels A, Levine RA, Slaugenhaupt SA, Goodwin RL, Pavone LM, Merot J, Schott JJ, Le Tourneau T, Dix T, Jesinkey S, Feng Y, Walsh C, Zhou B, Baldwin S, Markwald RR, Norris RA, Developmental basis for filamin-A-associated myxomatous mitral valve disease. Cardiovasc Res. 2012 Oct 1;96(1):109-19
1	J:154601 Seuntjens E, Nityanandam A, Miquelajauregui A, Debruyn J, Stryjewska A, Goebbels S, Nave KA, Huylebroeck D, Tarabykin V, Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors. Nat Neurosci. 2009 Nov;12(11):1373-80
1	J:294279 Shin M, Vaughn A, Momb J, Appling DR, Deletion of neural tube defect-associated gene Mthfd1l causes reduced cranial mesenchyme density. Birth Defects Res. 2019 Nov 15;111(19):1520-1534
1	J:162396 Sottocornola R, Royer C, Vives V, Tordella L, Zhong S, Wang Y, Ratnayaka I, Shipman M, Cheung A, Gaston-Massuet C, Ferretti P, Molnar Z, Lu X, ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development. Dev Cell. 2010 Jul 20;19(1):126-37
1	J:276593 Spella M, Kyrousi C, Kritikou E, Stathopoulou A, Guillemot F, Kioussis D, Pachnis V, Lygerou Z, Taraviras S, Geminin regulates cortical progenitor proliferation and differentiation. Stem Cells. 2011 Aug;29(8):1269-82
1	J:83727 Stenvers KL, Tursky ML, Harder KW, Kountouri N, Amatayakul-Chantler S, Grail D, Small C, Weinberg RA, Sizeland AM, Zhu HJ, Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol. 2003 Jun;23(12):4371-85
1	J:282575 Sudiwala S, Palmer A, Massa V, Burns AJ, Dunlevy LPE, de Castro SCP, Savery D, Leung KY, Copp AJ, Greene NDE, Cellular mechanisms underlying Pax3-related neural tube defects and their prevention by folic acid. Dis Model Mech. 2019 Nov 22;12(11):dmm042234
1	J:233479 Vong KI, Leung CK, Behringer RR, Kwan KM, Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum. Mol Brain. 2015;8:25
1	J:140167 Wakselman S, Bechade C, Roumier A, Bernard D, Triller A, Bessis A, Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor. J Neurosci. 2008 Aug 6;28(32):8138-43
1	J:238814 Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu WG, Qin J, Honig B, Gu W, Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016 Oct 06;538(7623):118-122
1	J:309152 Wang X, Wang H, Liu J, Gong Y, Zhang C, Fang F, Li A, Wu X, Shen Q, Xu H, Gen1 mutation caused kidney hypoplasia and defective ureter-bladder connections in mice. Int J Biol Sci. 2020;16(9):1640-1647
1	J:195044 Wang Y, Tian Y, Morley MP, Lu MM, Demayo FJ, Olson EN, Morrisey EE, Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway. Dev Cell. 2013 Feb 25;24(4):345-58
1	J:328987 Wang Y, Zong W, Sun W, Chen C, Wang ZQ, Li T, The Central Domain of MCPH1 Controls Development of the Cerebral Cortex and Gonads in Mice. Cells. 2022 Aug 31;11(17)
1	J:286739 Wazin F, Lovicu FJ, The negative regulatory Spred1 and Spred2 proteins are required for lens and eye morphogenesis. Exp Eye Res. 2020 Feb;191:107917
1	J:201674 Xie Y, Juschke C, Esk C, Hirotsune S, Knoblich JA, The phosphatase PP4c controls spindle orientation to maintain proliferative symmetric divisions in the developing neocortex. Neuron. 2013 Jul 24;79(2):254-65
1	J:150452 Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT, Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest. 2009 Jun;119(6):1462-76
1	J:166646 Zovein AC, Turlo KA, Ponec RM, Lynch MR, Chen KC, Hofmann JJ, Cox TC, Gasson JC, Iruela-Arispe ML, Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters. Blood. 2010 Nov 4;116(18):3435-44